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It can be used alongside caloric restriction without exacerbating hunger, combined with exercise programs without compromising fueling needs, or integrated with behavioral nutrition approaches that rely on intact hunger and satiety signaling for long-term habit formation

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Fu YY, He K, Phan S, Bhatia R, Pickford P, Wu N, Dzamko GM, Halliday WS, Kim

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Its sequence design incorporates non-natural amino acids that enhance receptor selectivity and reduce interaction with secondary endocrine pathways

These factors motivated us to refine the method for improved robustness